Download e-book for kindle: Antibacterial Agents: Chemistry, Mode of Action, Mechanisms by Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

ISBN-10: 0470972440

ISBN-13: 9780470972441

Antibacterial brokers act opposed to bacterial an infection both by means of killing the bacterium or via arresting its progress. They do that by way of focusing on bacterial DNA and its linked approaches, attacking bacterial metabolic tactics together with protein synthesis, or interfering with bacterial phone wall synthesis and function.

Antibacterial Agents is an important advisor to this significant type of chemotherapeutic medicines. Compounds are organised in keeping with their goal, which is helping the reader comprehend the mechanism of motion of those medicines and the way resistance can come up. The booklet makes use of an built-in “lab-to-clinic” strategy which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, medical features (including hyperlinks to present directions, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.

Agents coated include:

  • agents concentrating on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents concentrating on metabolic procedures -  sulfonamide antibacterial brokers and trimethoprim
  • agents concentrating on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents focusing on phone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Extra resources for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

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K. Chen, Mol. Cell. Proteomics, 2008, 7, 448–456. A. Huletsky, R. Giroux, V. Rossbach, M. Gagnon, M. Vaillancourt, M. Bernier, F. Gagnon, K. Truchon, M. Bastein, F. J. Pickard, A. van Belkum, M. Ouellette, P. H. Roy, and M. G. Bergeron, J. Clin. , 2004, 42, 1875–1884. K. W. Langford, B. Penkov, I. M. Derrington, and J. H. Gundlach, J. , 2011, 52, 272–277. B. S. Laursen, H. P. Srensen, K. K. Mortensen, and H. U. Sperling-Petersen, Microbiol. and Mol. Biol. , 2005, 69, 101–123. N. A. Ledeboer, K.

Nalidixic acid, like other first-generation quinolones, was found to have weak antibacterial (bactericidal) activity and is now only used for the treatment of urinary tract infections (UTIs) caused by Gram negative bacteria, as is norfloxacin, a second-generation quinolone. All second-generation and later quinolones contain, in addition to the 3-carboxyl-substituted quinolin-4one essential for biological activity, a fluorine at the 6-position and a cyclic amine at the 7-position, both of Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications, First Edition.

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