Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith PDF

By Derek Leroith

ISBN-10: 0762301589

ISBN-13: 9780762301584

Traditionally the sphere of endocrine learn has regularly been on the vanguard of medical endeavors. The investigators of those vital breakthroughs in examine were rewarded by means of various Nobel awards. within the box of diabetes on my own, Nobel prizes were provided to researchers who chanced on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. no longer strangely, biomedical researchers have consistently been attracted via the endocrine procedure and different comparable platforms of intercellular verbal exchange. over the last twenty years, endocrine study has built swiftly and tailored smooth molecular and mobile biology strategies for its particular use. those adjustments have allowed researchers within the box to keep up their side. therefore, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine problems. Our figuring out of the rules of gene expression has been vastly stronger by way of molecular recommendations. In an try to deliver investigators brand new with the hot advances during this exploding box we have now determined to post a sequence entitled Advances in Molecular and mobile Endocrinology. the world over well-known investigators have agreed to take part and their contributions are favored. quantity 1 has considering points of the hypothalamic-pituitary axis together with GnRH and GH gene rules, molecular facets of insulin, insulin-like progress components and glucagon. furthermore, stories at the lately cloned calcium receptor and steroid receptor interactions with DNA are provided.

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Extra info for Advances in Molecular and Cellular Endocrinology, Vol. 1

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COHEN, S. E. WONDISFORD Figure 2. Pit-1 splice variants. Thin lines represent Pit-1 splice events. Thick lines represent variant Pit-1 splice events: Pit-lT has the addition of the diagonally shaded area; Pit-113 had the addition of both the diagonally and dot shaded areas. , 1993). In gene transfer studies, D4Pit- 1 inhibits Prl promoter activity and, therefore, it may be a potential mediator ofPrl gene expression (Day and Day, 1994). A third variant, Pit- 1T, has been identified in thyrotroph-derived cells.

Steroid Biochem. Molec. Biol. 37, 899-902. D. (1990). Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta. Mol. Endocrinol. 4, 476-480. , & Lee, E. (1992). Characterization, expression,, & estradiol regulation of the human GnRH gene. ), pp. 85-104. Springer-Verlag, New York. E. (1991). Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 3402-3406. , Wray, S. E. (1994). Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.

L. (1995). Regulation of GnRH transcription by protein kinase C is mediated by evolutionarily conserved, promoter-proximal elements. Mol. Endocrinol. 9, 848-859. W. (1990). Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Neuroendocrinology 51,276-283. , & Hamada, H. (1993). A CNS specific POU transcription factor, Brn-2, is required for establishing mammalian neural lineages. Neuron 11, 1197-1206. G. (1993). 0: A POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.

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Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith


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