Download e-book for kindle: Advances in Cancer Research, Vol. 66 by George F. Vande Woude

By George F. Vande Woude

ISBN-10: 0120066661

ISBN-13: 9780120066667

ADVANCES IN melanoma study is a biannual ebook that incorporates well timed studies at the such a lot state-of-the-art concerns in melanoma examine. quantity sixty six includes encompassing overviews of p53 and its function in either breast melanoma and within the phone cycle. nearly 50% of all human tumors contain mutations of the p53 gene, suggesting that right knowing of its homes and mechanisms may well supply genuine wish for locating profitable scientific treatment. different topics offered in quantity sixty six contain cyclins and cyclin-dependent kinases within the mobilephone cycle. nearly 50% of all human tumors contain mutations of the p53 gene, suggesting that right knowing of its homes and mechanisms may perhaps provide actual desire for locating sucessful medical treatment. different issues awarded in quantity sixty six comprise cyclins and cyclin-dependant kinases within the mobile cycle: the molecular genetics of 11q23 chromosome translocations: the potential hyperlink among the aberrant expression of Scatter issue and c-Met with AIDS linked kaposi's Sarcoma, using Radiation Leukemia Virus to urge leukemogenesis, and the Adenovirus process as a version for the insertion of international DNA into mammalian genomes. additionally of observe within the ''Foundations of melanoma Research'' part are articles by means of trendy melanoma researchers recollecting the tips and paths taken of their lifelong paintings. Paradigms proposed in those reports mark considerate development towards preventative remedy in oncogenesis and gene remedy of melanoma. in addition they forged gentle at the undeniable fact that the guidelines provided in those chapters are just the top of the iceburg during this advanced and ever evolving box, and recommend many extra to return in destiny volumes. Key positive factors * comprises Foundations in melanoma learn articles with own debts through fashionable biologists on their careers in melanoma study * provides overviews of the position of p53 in breast melanoma and cellphone cycle legislation * Describes the regulatory function of cyclins and cyclin established kinases in DNA replication and telephone department * Explains the confusing hyperlink among HIV an infection and Kaposis Sarcoma * comprises types for retrovirus-induced tumorigenesis and overseas DNA insertion into mammalian genomes

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N a d Acad. Sci. USA 77, 6134-6138. Milstein, C . (1980). Mouoclonal antibodies. Scientif. Amer. 243 (4), 56-64. Mintz, U . , and Sachs, L. (1973). Normal granulocyte colony-forming cells in the bone marrow of Yemenite Jews with genetic neutropenia. Blood 41, 745-751. Moore, K. , and Barr, M. I,. (1954). Nuclear morphology, according to sex, in human tissues. Acta Anal. 21, 197. , and Keshet, E. (1990). Pattern of interleukin 6 gene expression in V ~ V Osuggests a role for this cytokine in angiogenesis.

A p ’ c . Sci. 34, 204-213. Sachs, L. (1953b). Chromosome behaviour in species hybrids with Triticum timopheevi. Heredity 7, 49-58. Sachs, L. T h e giant sex chromosomes in the mammal Microtus agrestis. Heredity 7 , 22 7-2 38. Sachs, L. (l953d). Simple methods for mammalian chromosomes. Stain Tpch. 28, 169-172. Sachs, L. (1953e). Sub-diploid chromosome variation in man and other mammals. Nature 172,205-206. Sachs, L. (1954a). T h e chromosome constancy of the normal mammalian uterus. Heredity 8, 117-124.

Cell Growth Dqjer. 5 , 321-327. , and Sachs, L. (1989). Regulation of megakaryocyte development by interleukin 6. Blood 74, 1545-1551. , and Sachs, L. (l99la). Rescue from programmed cell death in leukemic and normal myeloid cells. Blood 78, 953-960. , and Sachs, L. (1991b). T h e network of heinatopoietic regulatory proteins in myeloid cell differentiation. Cell Growth 0;ffer. 2, 42 1-427. Lowe, S. , Schmitt, E. , Smith, S. , Osborne, B. A,, and Jacks, T. (1993). 53 is required for radiation-induced apoptosis in niouse thymocytes.

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