By Philip W. Harvey, David J. Everett, Christopher J. Springall
Despite being considered as the commonest toxicological aim within the endocrine procedure, the adrenal gland has usually been ignored in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts to be had to ascertain adrenal endocrine disruption.
Examining present options and the newest developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents details at the diversity of substances and chemical substances that impact adrenocortical functionality and indicates standardized techniques for in vivo and in vitro evaluate. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.
Adrenal Toxicology :
- reflects the most important advancements remodeled the previous decade
- focuses at the most modern examine options, together with their makes use of and limitations
- provides an built-in procedure for adrenal toxicology evaluation
- identifies wisdom and knowledge gaps, delivering impetus for regulatory consideration
Read Online or Download Adrenal Toxicology PDF
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Extra resources for Adrenal Toxicology
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Further, hyperglycemia is also reported to worsen neurological injury particularly if mediated by ischemia or lactate acidosis (Wass and Lanier, 1996). , 2005), which may be beneficial in some tissues for the survival of acute insults. , 1993), and reduction of chemical efflux pumping of chemical toxicant out of cells would intuitively produce prolonged intracellular exposure and potentiate/exacerbate toxicity. Glucocorticoids, therefore, have different actions in different cells and tissues, and several mechanisms of glucocorticoid action may occur concurrently to variable degrees.
Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall