Read e-book online Adrenal Toxicology PDF

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the commonest toxicological aim within the endocrine procedure, the adrenal gland has usually been ignored in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts to be had to ascertain adrenal endocrine disruption.

Examining present options and the newest developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents details at the diversity of substances and chemical substances that impact adrenocortical functionality and indicates standardized techniques for in vivo and in vitro evaluate. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the most important advancements remodeled the previous decade
  • focuses at the most modern examine options, together with their makes use of and limitations
  • provides an built-in procedure for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, delivering impetus for regulatory consideration

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Extra resources for Adrenal Toxicology

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Neuro Endocrinol Lett 2005; 26:709–712. Kau MM, Kan SF, Wang JR, et al. Inhibitory effects of digoxin and ouabain on aldosterone synthesis in human adrenocortical NCI-H295R cells. J Cell Physiol 2005; 205:393– 401. Kempna P, Hofer G, Mullis PE, et al. Pioglitazone inhibits androgen production in NCIH295R cells by regulating gene expression of CYP17 and HSD3 B2. Mol Pharmacol 2007; 71:787–798. Khisti RT, Kumar S, Morrow AL. Ethanol rapidly induces steroid acute regulatory protein expression and translocation in rat adrenal gland.

Arch Environ Contam Toxicol 1992; 22:278–283. Hornsby PJ. Steroid and xenobiotic effects on the adrenal cortex: Mediation by oxidation and other mechanisms. Free Radical Biol Med 1989; 6:103–115. Imagawa K, Okayama S, Takaoka M, et al. Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. J Cardiovasc Pharmacol 2006; 47:133–138. Janossy A, Saez JM, Li JY. Carbachol induces homologus steroidogenic refractoriness of bovine fasciculata-reticularis cells.

Further, hyperglycemia is also reported to worsen neurological injury particularly if mediated by ischemia or lactate acidosis (Wass and Lanier, 1996). , 2005), which may be beneficial in some tissues for the survival of acute insults. , 1993), and reduction of chemical efflux pumping of chemical toxicant out of cells would intuitively produce prolonged intracellular exposure and potentiate/exacerbate toxicity. Glucocorticoids, therefore, have different actions in different cells and tissues, and several mechanisms of glucocorticoid action may occur concurrently to variable degrees.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


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