New PDF release: Acne and its therapy

By Guy F. Webster, Anthony V. Rawlings

ISBN-10: 0824729714

ISBN-13: 9780824729714

Addressing essentially the most more often than not encountered stipulations visible via the dermatologist, this resource analyzes the pathophysiology, overview, prognosis, medical positive factors, and keep an eye on of pimples. With full-color illustrations, this resource delves into the to be had healing procedures for tricky instances of pimples and scarring and offers specialist discussions of administration regimens together with topical and systemic cures, laser remedies, and new drugs.

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Example text

Hypercornification from the retention of desmosomes was described to be a contributory factor to the formation of acne lesions. However, no differences were detected between staining for these epitopes in the wall of normal and comedonal follicles (29). CONCLUSION Although it is clear that we now know a great deal about the pilosebaceous unit at the structural, biochemical, and physiological levels, there are still considerable gaps in our understanding. Much of the early work was descriptive biology of the structure obtained using immunohistochemical studies.

Furthermore, GH enhanced the effect of DHT on sebocyte differentiation perhaps complementing the effect of androgens in increasing sebum during puberty. IGFs, in contrast, had a greater effect on increasing DNA synthesis compared to GH, and had no effect on the response of the cell to DHT (159), although a role for IGF in causing the observed increase in sebum production at puberty has not been ruled out. This suggests that antagonists of IGF may offer a way of decreasing sebum synthesis. Corticotrophic-releasing hormone (CRH), a key regulator in the central nervous system, has been implicated in sebum production (160).

Activity of type 1 5 alpha-reductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol 1997; 136(2):166– 171. 110. Thiboutot D, Jabara S, McAllister JM, et al. Human skin is a steroidogenic tissue: steroidogenic enymes and cofactors are expressed in epidermis, normal sebocytes and an immortalised sebocyte cell line (SEB-1). J Invest Dermatol 2003; 120:905– 914. 111. Ideta R, Seki T, Adachi K, Nakayama Y. The isolation and characterization of androgendependent genes in the flank organs of golden Syrian hamsters.

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Acne and its therapy by Guy F. Webster, Anthony V. Rawlings


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