By Drew Provan
This moment variation of the ABC of scientific Haematology is a entire and sensible advisor to this broad ranging speciality, overlaying the haematological elements of such parts as pathology, molecular technology, melanoma, and normal drugs. this can be a brief quantity including chapters on all components of haematology written through those that take care of those illnesses every day. The booklet offers descriptions of those illnesses and describes the pathways serious about analysis and remedy. complete color is used all through this seriously illustrated e-book, utilizing medical fabric and textual content containers to emphasize key issues. we now have additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require large earlier wisdom.
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Serum urate concentration may be raised (Fig. 5). Management After diagnosis, the first priority is a frank discussion with the patient. 4). The clinician should explain the propensity of the disease to progress to an advanced phase. 5 Course of chronic myeloid leukaemia, showing progression to blastic phase. practice most patients are advised to start treatment with imatinib mesylate (Glivec ®; Novartis) or an imatinib-containing combination. Younger men should be offered cryopreservation of semen if necessary.
Fevers, night sweats and weight loss (hypermetabolic state) may be present and are associated with more advanced disease. Laboratory investigations Significant bone marrow fibrosis is the sine qua non of IMF. g. 6). The blood count in IMF is variable. In the initial ‘proliferative phase’, red cell production may be normal or even increased, and about half of presenting patients may have a raised white cell or platelet count (absence of the Philadelphia chromosome will distinguish from chronic myeloid leukaemia) (Fig.
The platelet count can vary from <5 × 109/L to near normal. 2). 5 Bleeding around the eye in a patient with Bernard-Soulier syndrome. • • • • • • • • • Drug-induced Leukaemia Metastatic tumour Aplastic anaemia Myelodysplasia Cytotoxic drugs Radiotherapy Associated with infection Megaloblastic anaemia 36 ABC of Clinical Haematology Neonatal alloimmune thrombocytopenia Neonatal alloimmune thrombocytopenia is similar to haemolytic disease of the newborn except that the antigenic stimulus comes from platelet specific antigens rather than red cell antigens.
ABC of Clinical Haematology (ABC Series) by Drew Provan