By H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler
Read or Download 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) PDF
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Extra resources for 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research)
However, it is yet to be determined whether ␤-cells are able to recover in patients with GHD, and risk for T2DM may persist even with low-dose therapy. Unfortunately, we did not have sufficient subject numbers for a complete long-term follow-up , but we were surprised to note that subjects treated with the standard GH dose rapidly reverted to baseline. In contrast, in the low-dose group, low fasting glucose levels and improved insulin sensitivity and secretion were still present 6 months after discontinuing GH therapy .
N Engl J Med 1936;214:961–985. 2 Rabinowitz D, Klassen GA, Zierler KL: Effects of human growth hormone on muscle and adipose tissue metabolism in the forearm of man. J Clin Invest 1965;44:51–61. 3 Møller N, Schmitz O, Jørgensen JO, Astrup J, Bak JF, Christensen SE, Alberti KG, Weeke J: Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. J Clin Endocrinol Metab 1992;74:1012–1019. 4 Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ: Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.
In the low-dose GH group, we observed a significant improvement in insulin sensitivity without any changes in free fatty acid levels or body composition; whereas, insulin sensitivity remained unchanged in the standard-dose GH group, despite improvements in body composition, and free fatty acid levels were increased. Thus, it would appear that low-dose GH replacement, which avoids increases in lipolysis, can indeed improve glucose metabolism in GH-deficient adults. Implications for GH Replacement in Adults with GHD Chronic administration of standard GH replacement doses in GH-deficient adults promotes insulin antagonism and may increase the risk for development of T2DM.
38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) by H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler